TH polyclonal Antibody | BS91341

TH polyclonal Antibody | BS91341 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC FC

Application Range: WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson's disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TH polyclonal Antibody detects endogenous levels of TH protein.

Molecular Weight: 58 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TH, Dystonia 14, DYT14, DYT5b, EC 1.14.16.2, OTTHUMP00000011225, OTTHUMP00000011226, ple, Protein Pale, TH, The, TY3H, TYH, Tyrosine 3 hydroxylase, Tyrosine 3 monooxygenase, Tyrosine 3-hydroxylase, Tyrosine 3-monooxygenase, Tyrosine hydroxylase,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: