(±)-Thalidomide | 2020

Cell-permeable. A teratogen and sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Thalidomide initiates its teratogenic effects by binding to cereblon (CRBN), a thalidomide-binding protein, and inhibiting the associated ubiquitin ligase activity.

(±)-Thalidomide is a teratogen and sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Thalidomide initiates its teratogenic effects by binding to cereblon (CRBN), a thalidomide-binding protein, and inhibiting the associated ubiquitin ligase activity.

2020 | (±)-Thalidomide DataSheet

Alternate Name/Synonyms: (RS)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione

Appearance: White solid

Formulation: N/A

CAS Number: 50-35-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₀N₂O₄

Molecular Weight: 258.23

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective inhibitor of tumor necrosis factor α (TNF-α) synthesis

MDL Number: MFCD00153873

PubChem CID: 5426

SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O

InChi: InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

InChi Key: UEJJHQNACJXSKW-UHFFFAOYSA-N