Thioredoxin polyclonal Antibody | BS91344

Thioredoxin polyclonal Antibody | BS91344 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF IHC IP

Application Range: WB:1:1,000 ICC:1:100-1:200 IHC:1:50-1:200

Background: Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFkB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. TrxR is a ubiquitously expressed flavoprotein that catalyzes the NADPH-dependent reduction of Trx as well as several other oxidized cellular components.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Thioredoxin polyclonal Antibody detects endogenous levels of Thioredoxin protein.

Molecular Weight: 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Trx, ADF, SASP, TXN, ADF, ATL derived factor, ATL-derived factor, DKFZp686B1993, MGC61975, SASP, Surface associated sulphydryl protein, Surface-associated sulphydryl protein, testicular tissue protein Li 199, THIO, Thioredoxin, thioredoxin delta 3, TRDX, TRX 1, Trx, TRX1, TXN, TXN delta 3, TXN protein, zgc:92903,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: