THOC7 Antibody (C-term) [APR32752G]

THOC7 Antibody (C-term) [APR32752G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This THOC7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the C-terminal region of human THOC7.

Cellular Localisation: Cytoplasm. Nucleus. Nucleus speckle. Note=Interaction with THOC5 is required for nuclear localization.

Molecular Weight: 23743

Clone: Polyclonal

Gene Name: THOC7

Gene ID: 80145

Function: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: THO complex subunit 7 homolog, Functional spliceosome-associated protein 24, fSAP24, Ngg1-interacting factor 3-like protein 1-binding protein 1, NIF3L1-binding protein 1, hTREX30, THOC7, NIF3L1BP1