THRB Antibody | 28-322

THRB Antibody | 28-322 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human THRB.

Research Area: Transcription, Cancer, Signal Transduction

Tested Application: E, WB

Application: THRB antibody can be used for detection of THRB by ELISA at 1:1562500. THRB antibody can be used for detection of THRB by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50, 000 - 100, 000.

Specificiy: N/A

Positive Control 1: Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 53 kDa

Validation: N/A

Isoform: N/A

Purification: Antibody is purified by peptide affinity chromatography method.

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Concentration: batch dependent

Storage Condition: For short periods of storage (days) store at 4˚C. For longer periods of storage, store THRB antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Alternate Name: THRB, GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR) , a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4) , with normal or slightly elevated thyroid stimulating hormone (TSH) . Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far.