Gentaur

Thrombin, Anti-Human, Rabbit, Polyclonal | 88-11571-05021

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Description
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Description

Thrombin, Anti-Human, Rabbit, Polyclonal | 88-11571-05021

Quality Level

100

biological source

human plasma

form

lyophilized

specific activity

~120 units/mg protein (At 25 °C with Chromozym TH as the substrate.)

mol wt

M_r ~33.6 kDa

packaging

pkg of 20 U

manufacturer/tradename

Roche

optimum pH

8.2-9.0

shipped in

wet ice

General description

Thrombin is a Na⁺ activated allosteric serine protease. It belongs to chymotrypsin family. Thrombin is made of two polypeptide chains of 36 (A chain) and 259 (B chain) residues that are covalently attached with a disulfide bond.

Thrombin is a coagulation factor IIa. It is a serine endopeptidase that hydrolyzes peptide and ester bonds specifically at the carboxylic side of Arg. The enzyme converts fibrinogen to fibrin. The product contains EDTA and additional stabilizing agents.

Application

Thrombin is used in coagulation research, medical research, protein-structure analysis, and biochemical research. It has been used for the stimulation of the platelets.

Thrombin has been used in the expression and purification of recombinant RELM (resistin-like moleculefamily members. It has also been used in platelet spreading on fibrinogen and immunostaining.

Biochem/physiol Actions

Thrombin plays an important role in blood coagulation. It serve as a procoagulant factor while transforming fibrinogen into an insoluble fibrin clot. Thrombin can act as anticoagulant by the activation of protein C.

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