TIGIT Antibody [10B1] (biotin) | RF16058-biotin

TIGIT Antibody [10B1] (biotin) | RF16058-biotin | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: TIGIT antibody was raised against the extracellular domain of human TIGIT

Research Area: Immunology

Tested Application: E

Application: TIGIT antibody can be used for as detection antibody in Sandwich Elisa at 1 μg/mL.

Specificiy: N/A

Positive Control 1: Cat. No. 1340 - Human Stomach Carcinoma Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: TIGIT Antibody is supplied as protein A purified IgG1.

Clonality: Monoclonal

Clone: 10B1

Isotype: IgG1

Conjugate: biotin

Physical State: Liquid

Buffer: TIGIT Antibody is supplied in PBS containing 1% BSA and 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TIGIT antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: TIGIT Antibody: T-cell immunoreceptor with Ig and ITIM domains, VSIG9, VSTM3, WUCAM

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH) . TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1) . Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2) .