TIGIT Detection Set | SD8800

TIGIT Detection Set | SD8800 | Gentaur UK, US & Europe Distribution

Host: llama

Reactivity: Human

Homology: N/A

Immunogen: TIGIT antibodies were raised against a recombinant protein corresponding to amino acids 22-141 of human TIGIT.

Tested Application: E, IHC-P, ICC, IF, Flow

Application: N/A

Specificity: N/A

Purification: TIGIT Antibodies are affinity chromatography purified via Nickel column. Antibodies are supplied as a His-tagged purified protein.  They also contains a myc-tag for detection.

Clonality: Monoclonal

Isotype: sdab

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TIGIT Antibodies are supplied in PBS.

Concentration: Antibody 1 mg/mL

Storage Condition: TIGIT antibodies should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Background: TIGIT Antibody: The T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins. It is expressed on several classes of T cells including follicular B helper T cells (TFH). TIGIT has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses (1). Similar to other immune checkpoint proteins such as PD-1, TIGIT is upregulated on exhausted T cells in chronic viral infections and cancer. Blockade of both TIGIT and PD-1 pathways leads to tumor rejection in mice suggesting that it may be of therapeutic use against cancer (2).

User Note: Optimal dilutions for each application to be determined by the researcher.