TIPRL Antibody (C-term) [AMM08208G]

TIPRL Antibody (C-term) [AMM08208G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TIPRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-218 amino acids from the C-terminal region of human TIPRL.

Cellular Localisation: Cytoplasm.

Molecular Weight: 31444

Clone: Polyclonal

Gene Name: TIPRL

Gene ID: 261726

Function: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A) . Isoform 1 inhibits catalytic activity of the PP2A (D) core complex in vitro. The PP2A (C) :TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine- protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX) . May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: TIP41-like protein, Putative MAPK-activating protein PM10, Type 2A-interacting protein, TIP, TIPRL