TLR6 Antibody| F44376-0.08ML/F44376-0.4ML/RQ6688

TLR6 Antibody| F44376-0.08ML/F44376-0.4ML/RQ6688 | Gentaur UK, US & Europe Distribution

Background: TLR6, a Type I membrane protein that belongs to the Toll-like rceptor family, participates in the innate immune response to Gram-positive bacteria and fungi. It acts via MyD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. The protein recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. It binds to TLR2 via their respective extracellular domains, and to MyD88 via their respective TIR domains. TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: FACS, WB, IHC, ELISA

Application Details: Flow Cytometry: 1:10-1:50, Western blot: 1:1000, IHC (Paraffin): 1:50-1:100

Application Note: Titration of the TLR6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This TLR6 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 393-423 from the human protein was used as the immunogen for this TLR6 antibody.

Storage: Aliquot the TLR6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A