TLX1 Antibody | 7361

TLX1 Antibody | 7361 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: TLX1 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX1.
The immunogen is located within the first 50 amino acids of TLX1.

Research Area: Stem Cell

Tested Application: E, WB, IHC-P

Application: TLX1 antibody can be used for detection of TLX1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Specificiy: Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins.

Positive Control 1: Cat. No. 1406 - Mouse Spleen Tissue Lysate

Positive Control 2: Cat. No. 10-901 - Human Spleen Tissue Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 36 kDa
Observed: 35 kDa

Validation: N/A

Isoform: N/A

Purification: TLX1 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TLX1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TLX1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: TLX1 Antibody: TCL3, HOX11, TCL3, T-cell leukemia homeobox protein 1, Homeobox protein Hox-11

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TLX1 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11) , as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.