TMEM59 Polyclonal Antibody | BS65698

TMEM59 Polyclonal Antibody | BS65698 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,

Application: WB,

Application Range: WB=1:500-2000

Background: TMEM59 is a 144 amino acid protein encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TMEM59 Polyclonal Antibody detects endogenous levels of TMEM59 protein.

Molecular Weight: 33 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: C1orf8; HSPC001; Liver membrane-bound protein; TMEM59; TMEM59 transmembrane protein 59; TMM59_HUMAN; Transmembrane protein 59. 

Immunogen: KLH conjugated synthetic peptide derived from human TMEM59:141-240/323

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: