TMP269 | 2679

TMP269 is a potent, selective and cell-permeable class IIa HDAC inhibitor (IC₅₀ values of of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively). Displays 20-400 fold selectivity over class I HDACs.

TMP269 is a potent, selective and cell-permeable class IIa HDAC inhibitor (IC₅₀ values of of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively). Displays 20-400 fold selectivity over class I HDACs.

2679 | TMP269 DataSheet

Alternate Name/Synonyms: N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; TMP-269

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1314890-29-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₁F₃N₄O₃S

Molecular Weight: 514.52

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent class IIa HDAC inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4

InChi: InChI=1S/C25H21F3N4O3S/c26-25(27,28)22-31-20(32-35-22)17-7-4-8-18(13-17)21(33)29-15-24(9-11-34-12-10-24)23-30-19(14-36-23)16-5-2-1-3-6-16/h1-8,13-14H,9-12,15H2,(H,29,33)

InChi Key: HORXBWNTEDOVKN-UHFFFAOYSA-N