TMPRSS11D Antibody (N-Term) [ApR04905G]

TMPRSS11D Antibody (N-Term) [ApR04905G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TMPRSS11D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-119 amino acids from human TMPRSS11D.

Cellular Localisation: Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted

Molecular Weight: 46263

Clone: Polyclonal

Gene Name: TMPRSS11D

Gene ID: 9407

Function: May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.

Summary: Tissue Location: Located in the cells of the submucosal serous glands of the bronchi and trachea

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Transmembrane protease serine 11D, 3421-, Airway trypsin-like protease, Transmembrane protease serine 11D non-catalytic chain, Transmembrane protease serine 11D catalytic chain, TMPRSS11D, HAT