TNF-Alpha Antibody [MAb11] (PE) | 77-184

TNF-Alpha Antibody [MAb11] (PE) | 77-184 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: N/A

Research Area: Innate Immunity, Chemokines & Cytokines, Growth Factors, Apoptosis

Tested Application: Flow

Application: N/A

Specificiy: The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha) , a 157 amino acid non-glycosylated protein.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Clonality: Monoclonal

Clone: MAb11

Isotype: Mouse IgG1, kappa

Conjugate: PE

Physical State: liquid

Buffer: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Concentration: batch dependent

Storage Condition: The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.

Alternate Name: DIF, TNFA, TNFSF2, TNF-alpha, TNF

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha) , a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.