Tobramycin | B1537

Tobramycin is an aminoglycoside antibiotic that binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding. Tobramycin is used to treat Pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis, and other soft-tissue infections.

Tobramycin is an aminoglycoside antibiotic that binds irreversibly to one of two aminoglycoside binding sites on the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16S rRNA (ribosomal RNA). It inhibits translocation and elicits miscoding.

B1537 | Tobramycin DataSheet

Alternate Name/Synonyms: O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1-6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1-4)]-2-deoxy-D-streptamine

Appearance: White solid

Formulation: N/A

CAS Number: 32986-56-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₃₇N₅O₉

Molecular Weight: 467.52

Cell-Permeable?: Yes

Purity: ≥94%(Titration)

Solubilities: H₂O (>45 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An aminoglycoside antibiotic

MDL Number: MFCD00077885

PubChem CID: 36294

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N

InChi: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1

InChi Key: NLVFBUXFDBBNBW-PBSUHMDJSA-N