TOMM70A Antibody (C-term) [APR07197G]

TOMM70A Antibody (C-term) [APR07197G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TOMM70A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 579-608 amino acids from the C-terminal region of human TOMM70A.

Cellular Localisation: Mitochondrion outer membrane; Single-pass membrane protein

Molecular Weight: 67455

Clone: Polyclonal

Gene Name: TOMM70 (HGNC:11985)

Gene ID: 9868

Function: Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) . Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792) . Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199) . Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70 kDa subunit, TOMM70A, KIAA0719, TOM70