Torcetrapib | 2420

Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels. However, in clinical trials, Torcetrapib displayed unfavorable off-target effects in cardiovascular system. PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.

Torcetrapib is a cholesteryl ester transfer protein (CETP) inhibitor (IC₅₀ = 37 nM). It raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol levels.

2420 | Torcetrapib DataSheet

Alternate Name/Synonyms: (2R,4S)-ethyl 2-ethyl-4-(methoxycarbonyl)-6-(trifluoromethyl)-3,4-dihydroquinoline-1(2H)-carboxylate; CP-529414, CP529414, CP 529414

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 262352-17-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₂₅F₉N₂O₄

Molecular Weight: 600.47

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (>100 mg/ml) or EtOH (>5 mg/ml)

Handling: Protect from light and ai

Country of Origin: USA

Tag Line: A CETP inhibitor

MDL Number: N/A

PubChem CID: 159325

SMILES: CCC1CC(C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C(=O)OC

InChi: InChI=1S/C26H25F9N2O4/c1-4-18-12-21(19-11-15(24(27,28)29)6-7-20(19)37(18)23(39)41-5-2)36(22(38)40-3)13-14-8-16(25(30,31)32)10-17(9-14)26(33,34)35/h6-11,18,21H,4-5,12-13H2,1-3H3/t18-,21+/m1/s1

InChi Key: CMSGWTNRGKRWGS-NQIIRXRSSA-N