Torin 1 | 2273

A potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively; Torin1 displays 1000-fold selectivity for mTOR over PI3K (EC₅₀ = 1800 nM) and exhibits 100-fold binding selectivity relative to 450 other protein kinases.

Torin 1 is a potent, selective and ATP-competitive mTOR inhibitor, with IC₅₀ values of 2 and 10 nM for mTORC1 and mTORC2 respectively.

2273 | Torin 1 DataSheet

Alternate Name/Synonyms: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl­]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benz­o[h]-1,6-naphthyridin-2(1H)-one

Appearance: Slightly pinkish solid

Formulation: N/A

CAS Number: 1222998-36-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₅H₂₈F₃N₅O₂

Molecular Weight: 607.62

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent mTOR inhibitor

MDL Number: MFCD18782653

PubChem CID: 49836027

SMILES: CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F

InChi: InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3

InChi Key: AKCRNFFTGXBONI-UHFFFAOYSA-N