TPP2 polyclonal Antibody | BS8204

TPP2 polyclonal Antibody | BS8204 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IF

Application Range: WB: 1:500~1:2000 IF: 1:50~1:200

Background: Tripeptidyl peptidase II (TPPII), is a large intracellular serine exopeptidase with a subtilisin active site . TPPII protein is larger than the 26S proteasome and has a rod-shaped, dynamic supramolecular structure . TPPII is highly conserved among species and it sequentially removes tripeptides from the free amino-terminus of short peptides. TPPII has enhanced activity in proteosome inhibitor-adapted cells and degrades polypeptides by exo- as well as predominantly trypsin-like endoproteolytic cleavage. TPPII participates in the apoptotic pathway triggered by Shigella and is also involved in apoptosis induced by ATP and the protein kinase inhibitor staurosporine . Overexpression of TPPII is sufficient to prevent accumulation of polyubiquitinated proteins and partially restores peptide loading of MHC molecules . TPPII is able to compromise proteosome activity and normalize the rate of intracellular protein breakdown, which is required for normal cellular function and viability.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TPP2 polyclonal Antibody detects endogenous levels of TPP2 protein.

Molecular Weight: ~ 138 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Tripeptidyl-peptidase 2; TPP-2; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II; TPP-II; TPP2

Immunogen: Recombinant full length Human TPP2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: