TRAF2 Antibody | 3661

TRAF2 Antibody | 3661 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: TRAF2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TRAF2.
The immunogen is located within the last 50 amino acids of TRAF2.

Research Area: Signal Transduction, Cancer

Tested Application: E, WB, IHC-P, IP

Application: TRAF2 antibody can be used for the detection of TRAF2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Specificiy: N/A

Positive Control 1: Cat. No. 1404 - Mouse Liver Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 53 kDa

Validation: N/A

Isoform: N/A

Purification: TRAF2 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TRAF2 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TRAF2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: TRAF2 Antibody: TRAP, TRAP3, MGC:45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TRAF2 Antibody: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a TNF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-κB activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.