Description
TRAF2 Antibody, KO Validated | 13-338 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human TRAF2 (NP_066961.2) .
Research Area: Apoptosis, Autophagy, Cancer, Cell Cycle, Growth Factors, Immunology, Signal Transduction
Tested Application: WB, IF, IP
Application: WB: 1:500 - 1:2000
IF: 1:50 - 1:100
IP: 1:50 - 1:100
Specificiy: N/A
Positive Control 1: HeLa
Positive Control 2: 293T
Positive Control 3: THP-1
Positive Control 4: PC-12
Positive Control 5: Ramos
Positive Control 6: Jurkat
Molecular Weight: Observed: 54kDa
Validation: Antibody is Knockout validated.
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: TRAF2 Antibody: TRAP, TRAP3, MGC:45012, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs) , and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.