TRAF3IP2 Antibody (C-term) [AMM08697G]

TRAF3IP2 Antibody (C-term) [AMM08697G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TRAF3IP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human TRAF3IP2.

Cellular Localisation: N/A

Molecular Weight: 64666

Clone: Polyclonal

Gene Name: TRAF3IP2 (HGNC:1343)

Gene ID: 10758

Function: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828) . Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828) . Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361) . Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828) .

Summary: Tissue Location: Widely expressed.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Adapter protein CIKS, Connection to IKK and SAPK/JNK, Nuclear factor NF-kappa-B activator 1, ACT1, TRAF3-interacting protein 2, TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6