TRAF6 Antibody (Center) [APR31849G]

TRAF6 Antibody (Center) [APR31849G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TRAF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-343 amino acids from the Central region of human TRAF6.

Cellular Localisation: Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet {ECO:0000250|UniProtKB:P70196}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity) .

Molecular Weight: 59573

Clone: Polyclonal

Gene Name: TRAF6

Gene ID: 7189

Function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907, PubMed:18347055, PubMed:19713527, PubMed:19465916) . Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (PubMed:19675569) . Leads to the activation of NF-kappa-B and JUN (PubMed:16378096, PubMed:17135271) . Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity) . Represses c-Myb-mediated transactivation, in B-lymphocytes (PubMed:18093978, PubMed:18758450) . Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor (PubMed:8837778, PubMed:19825828, PubMed:12140561) . Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF- kappa-B, in response to RANK-L stimulation (By similarity) . Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity) .

Summary: Tissue Location: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: TNF receptor-associated factor 6, 632-, E3 ubiquitin-protein ligase TRAF6, Interleukin-1 signal transducer, RING finger protein 85, TRAF6, RNF85