TRAIL Antibody [HS501] | 36-136

TRAIL Antibody [HS501] | 36-136 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: Recombinant human TRAIL.

Research Area: Cancer, Immunology

Tested Application: WB

Application: Western Blot: (1:1000) .

Specificiy: Recognizes human TRAIL.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: >95% (SDS-PAGE)

Clonality: Monoclonal

Clone: HS501

Isotype: IgG1

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.

Alternate Name: Apo-2L; TNFSF10; CD253

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2; CD261; TNFRSF10A) , TRAIL-R2 (DR5; KILLER; TRICK2A; TRICK2B; CD262; TNFRSF10B) , TRAIL-R3 (DcR1; LIT; TRID; CD263; TNFRSF10C) , TRAIL-R4 (DcR2; TRUNDD; CD264; TNFRSF10D) , and osteoprotegerin (OPG; OCIF; TNFRSF11B) . Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC) . .