Description
TRAIL-R1 Antibody [HS101] (biotin) | 36-124 | Gentaur UK, US & Europe Distribution
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: Recombinant human TRAIL-R1 (DR4) .
Research Area: Apoptosis, Cancer, Immunology, Functional Assays
Tested Application: Flow, Func, ICC, IP
Application: Functional Application: Inhibition (blocks TRAIL-R1 mediated killing if applied in solution) .
Specificiy: Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: >95% (SDS-PAGE)
Clonality: Monoclonal
Clone: HS101
Isotype: IgG1
Conjugate: Biotin
Physical State: Liquid
Buffer: Liquid. In PBS containing 0.02% sodium azide.
Concentration: 0.5 mg/ml
Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.
Alternate Name: TRAIL Receptor 1; DR4; APO2; TNFRSF10A; CD261
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.