Description
TRAIL-R1 Antibody [TR1.02] | 36-137 | Gentaur UK, US & Europe Distribution
Host: Mouse
Reactivity: Human
Homology: N/A
Immunogen: Recombinant human TRAIL-R1 (DR4) .
Research Area: Cancer, Immunology
Tested Application: Flow, IHC, WB
Application: Immunohistochemistry: (paraffin sections) (20ug/ml) . Western Blot: (1ug/ml) . Optimal conditions must be determined individually for each application.
Specificiy: Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: >95% (SDS-PAGE)
Clonality: Monoclonal
Clone: TR1.02
Isotype: IgG2b
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Concentration: 1 mg/ml
Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.
Alternate Name: TRAIL Receptor 1; DR4; APO2; TNFRSF10A; CD261
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.