TRAIL-R2 Antibody [TR2.21] | 36-138

TRAIL-R2 Antibody [TR2.21] | 36-138 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: Recombinant human TRAIL-R2 (DR5) .

Research Area: Cancer, Immunology

Tested Application: Flow, IHC, WB

Application: Immunohistochemistry: (paraffin sections) (20ug/ml) . Western Blot: (1ug/ml) . Optimal conditions must be determined individually for each application.

Specificiy: Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: >95% (SDS-PAGE)

Clonality: Monoclonal

Clone: TR2.21

Isotype: IgG1

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage Condition: Stable for at least 1 year after receipt when stored at -20˚C.

Alternate Name: TRAIL Receptor 2; DR5; KILLER; TNFRSF 10B; CD262

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.