TRAP Antibody (N-term) [APR05766G]

TRAP Antibody (N-term) [APR05766G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-62 amino acids from the N-terminal region of human TRAP.

Cellular Localisation: Cell membrane; Single-pass type II membrane protein. Cell surface

Molecular Weight: 29274

Clone: Polyclonal

Gene Name: CD40LG

Gene ID: 959

Function: Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973) . Costimulates T-cell proliferation and cytokine production (PubMed:8617933) . Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933) . Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973) . Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037) . Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037) . Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity) . Involved in immunoglobulin class switching (By similarity) .

Summary: Tissue Location: Specifically expressed on activated CD4+ T- lymphocytes

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, IF, FC

Dilution: WB--1:1000 IHC-P--1:100~500 IF--1:10~50 FC--1:10~50

Synonyms: CD40 ligand, CD40-L, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5, CD154, CD40 ligand, membrane form, CD40 ligand, soluble form, CD40LG, CD40L, TNFSF5, TRAP