TRIM56Antibody (C-term) [APR30849G]

TRIM56Antibody (C-term) [APR30849G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TRIM56 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 727-755 amino acids from the C-terminal region of human TRIM56.

Cellular Localisation: Cytoplasm.

Molecular Weight: 81488

Clone: Polyclonal

Gene Name: TRIM56

Gene ID: 81844

Function: E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118) . In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'- linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity) . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA) -induced expression of IFNB1 and interferon- stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3- mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160) .

Summary: Tissue Location: Widely expressed (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: E3 ubiquitin-protein ligase TRIM56, 632-, RING finger protein 109, Tripartite motif-containing protein 56, TRIM56, RNF109