Triptolide | 1761

Triptolide, a diterpenoid triepoxyde, a purified component of a traditional Chinese medicine, inhibits transcriptional activation of NF- κB and downregulates the expression of various NF- κB-regulated genes. Displays Immunosuppressive, anti-inflammatory, anti-angiogenic and antitumor activity. A combination of TRAIL and triptolide enhance apoptosis in cholangiocarcinoma cell lines.

Triptolide, a diterpenoid triepoxyde, a purified component of a traditional Chinese medicine, inhibits transcriptional activation of NF- κB and downregulates the expression of various NF- κB-regulated genes. Displays Immunosuppressive, anti-inflammatory, anti-angiogenic and antitumor activity.

1761 | Triptolide DataSheet

Alternate Name/Synonyms: TPL

Appearance: Off-white solid

Formulation: N/A

CAS Number: 38748-32-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₄O₆

Molecular Weight: 360.4

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (20 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A NF-kappaB inhibitor

MDL Number: MFCD00210565

PubChem CID: 107985

SMILES: CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C

InChi: InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChi Key: DFBIRQPKNDILPW-CIVMWXNOSA-N