Trk A (A785) polyclonal Antibody | BS1430

Trk A (A785) polyclonal Antibody | BS1430 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: IHC IF

Application Range: IHC: 1:50~1:200 IF: 1:50~1:200

Background: TrkA is a high affinity nerve growth factor (NGF) . The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Trk A (A785) polyclonal Antibody detects endogenous levels of Trk A protein.

Molecular Weight: ~ 87, 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; Trk-A; gp140trk; p140-TrkA; NTRK1; MTC; TRK; TRKA

Immunogen: Synthetic peptide, corresponding to amino acids 751-800 of Human Trk A.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: