TrkA | Tyrosine Kinase Receptor A | AS13 2698

TrkA | Tyrosine Kinase Receptor A | AS13 2698 | Gentaur UK, US & Europe Distribution

Immunogen: Extracellular domain of glycosylated human TrkA protein produced in CHO cells was used as the immunogen,

Host: Rabbit

Conjugation: N/A

Clonality: Polyclonal

Isotype: N/A

Purity: Serum

Format: Lyophilized

Tested Application: ELISA (ELISA), Immunohistochemistry (IHC)

Related Products: N/A

Recommended Dilutions: 1 : 5000 (1-site ELISA), 1 : 1000 (IHC), Optimal dilutions/concentrations should be determined by the end user

Molecular weight: N/A

Confirmed Reactivity: Human, Rat, Mouse

Predicted Reactivity: N/A

Not reactive in: N/A

Additional Information: N/A

Background: TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF) . TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating.

Reconstitution: For reconstitution add 100 µl of sterile water

Storage: After reconstitution keep aliquots at -20ºC for a higher stability. and at 4ºC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

TAIR Nnumbre: N/A

Category: Neurobiology

Research Area: Neurobiology