Tropodithietic Acid | B1867

Tropodithietic acid is a broad spectrum tropolone antibiotic with activity against both Gram-negative and Gram-positive bacteria. Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress). A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.

Tropodithietic acid is a broad spectrum tropolone antibiotic with activity against both Gram-negative and Gram-positive bacteria. Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress). A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.

B1867 | Tropodithietic Acid DataSheet

Alternate Name/Synonyms: 3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid

Appearance: Orange solid

Formulation: N/A

CAS Number: 750590-18-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₈H₄O₃S₂

Molecular Weight: 212.3

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A broad spectrum tropolone antibiotic with activity against both Gram-negative and Gram-positive bacteria

MDL Number: N/A

PubChem CID: 44632924

SMILES: C1=CC(=O)C(=C2C(=C1)SS2)C(=O)O

InChi: InChI=1S/C8H4O3S2/c9-4-2-1-3-5-7(13-12-5)6(4)8(10)11/h1-3H,(H,10,11)

InChi Key: BLFCMITWMARUSM-UHFFFAOYSA-N