Tropomyosin 1 polyclonal Antibody | BS91377

Tropomyosin 1 polyclonal Antibody | BS91377 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC FC

Application Range: WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100

Background: Tropomyosins are a group of structural proteins. Tropomyosins are present in virtually all eukaryotic cells, both muscle and non-muscle, where they bind Actin filaments and function to modulate Actin-Myosin interaction and stabilize Actin filament structure. Tropomyosin α is encoded by the TPM1 gene, which maps to human chromosome 15q22.1 and undergoes alternative splicing to generate at least four isoforms, including skeletal muscle (isoform 1), smooth muscle (isoform 2), fibroblast/TM3 (isoform 3) and isoform 4. Tropomyosin β is encoded by the TPM2 gene, which maps to human chromosome 9p13.3 and undergoes alternative splicing to generate three isoforms, including skeletal muscle (isoform 1), non-muscle/fibroblast TM36/epithelial TMe1 (isoform 2) and non-muscle (isoform 3) . Troponin I binds Tropomyosin at a specific region and the association of Tropomyosin-Troponin with Actin filaments may increase the rigidity of Actin filaments. Tropomyosin also interacts with Caldesmon to regulate smooth muscle contraction.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Tropomyosin 1 polyclonal Antibody detects endogenous levels of Tropomyosin 1 protein.

Molecular Weight: 33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: TPM1, C15orf13, TMSA, AA986836, AI854628, Alpha tropomyosin, alpha-TM, Alpha-tropomyosin, C15orf13, cardiomyopathy, hypertrophic 3, CMD1Y, CMH3, HTM alpha, HTM-alpha, OTTHUMP00000163688, sarcomeric tropomyosin kappa, TM2, Tmpa, TMSA, Tpm-1, TPM1, TPM1, tropomyosin 1 (alpha), tropomyosin 1 (alpha) isoform 1, tropomyosin 1 (alpha) isoform 2, tropomyosin 1 (alpha) isoform 3, tropomyosin 1 (alpha) isoform 4, tropomyosin 1 (alpha) isoform 5, tropomyosin 1 (alpha) isoform 6, tropomyosin 1 (alpha) isoform 7, Tropomyosin 1, Tropomyosin alpha 1 chain, Tropomyosin alpha-1 chain, Tropomyosin, skeletal muscle alpha, Tropomyosin-1,

Immunogen: Recombinant protein within human Tropomyosin 1 aa 100-300.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: