TRPC3 Antibody | 3895

TRPC3 Antibody | 3895 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Rat: (100%)

Immunogen: TRPC3 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TRPC3.
The immunogen is located within amino acids 120 - 170 of TRPC3.

Research Area: Signal Transduction, Neuroscience, Infectious Disease

Tested Application: E, WB, IHC-P

Application: TRPC3 antibody can be used for the detection of TRPC3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Specificiy: This antibody may cross-react with TRPC6 and TRPC7.

Positive Control 1: Cat. No. 1301 - Human Heart Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 93 kDa
Observed: 100 kDa

Validation: N/A

Isoform: N/A

Purification: TRPC3 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: TRPC3 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: TRPC3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: TRPC3 Antibody: TRP3, TRP3, Short transient receptor potential channel 3, Transient receptor protein 3, TrpC3

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: TRPC3 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca²⁺-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.