TRPC4AP Antibody (N-term) [AMM08348G]

TRPC4AP Antibody (N-term) [AMM08348G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TRPC4AP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-75 amino acids from the N-terminal region of human TRPC4AP.

Cellular Localisation: Cytoplasm, perinuclear region

Molecular Weight: 90852

Clone: Polyclonal

Gene Name: TRPC4AP {ECO:0000303|PubMed:20551172, ECO:0000312|HGNC:HGNC:16181}

Gene ID: 26133

Function: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948) . The DCX (TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948) . The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948) . The DCX (TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948) . Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity) . Involved in JNK activation via its interaction with TRAF2 (By similarity) . Also involved in elevation of endoplasmic reticulum Ca (2+) storage reduction in response to CHRM1 (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Short transient receptor potential channel 4-associated protein, Trp4-associated protein, Trpc4-associated protein, Protein TAP1, TNF-receptor ubiquitous scaffolding/signaling protein, Protein TRUSS, TRPC4AP, C20orf188, TRRP4AP