TRPM8 Antibody| F41609-0.08ML/F41609-0.4ML/R32272

TRPM8 Antibody| F41609-0.08ML/F41609-0.4ML/R32272 | Gentaur UK, US & Europe Distribution

Background: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100

Application Note: Titration of the TRPM8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This TRPM8 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 69-98 from the human protein was used as the immunogen for this TRPM8 antibody.

Storage: Aliquot the TRPM8 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A