TSC2 Antibody (Center S1418/S1420) [APR10577G]

TSC2 Antibody (Center S1418/S1420) [APR10577G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1397-1426 amino acids from the Central region of human TSC2.

Cellular Localisation: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes

Molecular Weight: 200608

Clone: Polyclonal

Gene Name: TSC2

Gene ID: 7249

Function: In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400) . Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059) . May also play a role in microtubule-mediated protein transport (By similarity) . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity) .

Summary: Tissue Location: Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: IHC-P--1:100~500 WB--1:1000

Synonyms: Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4