TTK Antibody | 18-671

TTK Antibody | 18-671 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 517-856 of human TTK (NP_001160163.1) .

Research Area: Apoptosis, Cell Cycle, Signal Transduction

Tested Application: WB, IHC

Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:100

Specificiy: N/A

Positive Control 1: U-251MG

Positive Control 2: Mouse testis

Positive Control 3: Mouse spleen

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 97kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: CT96, ESK, MPH1, MPS1, MPS1L1, PYT, dual specificity protein kinase TTK, cancer/testis antigen 96, monopolar spindle 1 kinase, monopolar spindle 1-like 1, phosphotyrosine picked threonine kinase, phosphotyrosine picked threonine-protein kinase

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.