TTLL4 Antibody (Center) [APR30981G]

TTLL4 Antibody (Center) [APR30981G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TTLL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-493 amino acids from the Central region of human TTLL4.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:Q80UG8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80UG8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80UG8} Note=Located in cilia. In some cells, also found in basal bodies {ECO:0000250|UniProtKB:Q80UG8}

Molecular Weight: 133378

Clone: Polyclonal

Gene Name: TTLL4 (HGNC:28976)

Gene ID: 9654

Function: Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side- chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Tubulin polyglutamylase TTLL4, 6---, Tubulin--tyrosine ligase-like protein 4, TTLL4, KIAA0173