TUSC5 Antibody (Center) [APR10612G]

TUSC5 Antibody (Center) [APR10612G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TUSC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-104 amino acids from the Central region of human TUSC5.

Cellular Localisation: Cell membrane {ECO:0000250|UniProtKB:Q8C838}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838} Endomembrane system {ECO:0000250|UniProtKB:Q8C838}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8C838}. Note=Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation {ECO:0000250|UniProtKB:Q8C838}

Molecular Weight: 19254

Clone: Polyclonal

Gene Name: TRARG1 (HGNC:29592)

Gene ID: 286753

Function: Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.

Summary: Tissue Location: Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825) . Expressed in adipose tissue (PubMed:26629404)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Tumor suppressor candidate 5, Dispanin subfamily B member 1, DSPB1, Interferon-induced transmembrane domain-containing protein D3, Protein located at seventeen-p-thirteen point three 1, TUSC5, IFITMD3, LOST1