TXN Antibody [AMM22267G]

TXN Antibody [AMM22267G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H

Specificity: This antibody is generated from a mouse immunized with a recombinant protein from human.

Cellular Localisation: Nucleus. Cytoplasm. Secreted Note=Translocates from the cytoplasm into the nucleus after phorbol 12- myristate 13-acetate induction (PMA) (PubMed:9108029) . Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054) . Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054) . Secreted by a leaderless secretory pathway (PubMed:1332947) .

Molecular Weight: 11737

Clone: Monoclonal

Gene Name: TXN

Gene ID: 7295

Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:2176490, PubMed:17182577, PubMed:19032234) . Plays a role in the reversible S- nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900) . Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:9108029, PubMed:11118054) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Thioredoxin, Trx, ATL-derived factor, ADF, Surface-associated sulphydryl protein, SASP, TXN, TRDX, TRX, TRX1