TXNIP Polyclonal Antibody | BS65874

TXNIP Polyclonal Antibody | BS65874 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Rabbit,

Application: FCM,

Application Range: Flow-Cyt=1ug/test

Background: TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. It interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells (from SwissProt) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -47°C long term. Avoid freeze-thaw cycles.

Specificity: TXNIP Polyclonal Antibody detects endogenous levels of TXNIP protein.

Molecular Weight: ~44kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: THIF; thioredoxin binding protein 2; thioredoxin interacting protein; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1; Vitamin D3 up-regulated protein 1; TXNIP_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human TXNIP:101-200/391

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: