TXNL2 Antibody (N-term) [AMM08404G]

TXNL2 Antibody (N-term) [AMM08404G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This TXNL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human TXNL2.

Cellular Localisation: Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9CQM9}. Note=Under the plasma membrane (By similarity) . After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity) . In the Z line, found associated with CSRP3 (By similarity) . {ECO:0000250|UniProtKB:Q9CQM9}

Molecular Weight: 37432

Clone: Polyclonal

Gene Name: GLRX3

Gene ID: 10539

Function: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (PubMed:26613676, PubMed:27519415) . Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity) . Required for hemoglobin maturation (PubMed:23615448) . Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.

Summary: Tissue Location: Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Glutaredoxin-3, PKC-interacting cousin of thioredoxin, PICOT, PKC-theta-interacting protein, PKCq-interacting protein, Thioredoxin-like protein 2, GLRX3, PICOT, TXNL2