TYK2 Antibody (C-term) [AMM08407G]

TYK2 Antibody (C-term) [AMM08407G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This TYK2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 887-922 amino acids from the C-terminal region of human TYK2.

Cellular Localisation: N/A

Molecular Weight: 133650

Clone: Polyclonal

Gene Name: TYK2

Gene ID: 7297

Function: Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity (PubMed:10995743, PubMed:10542297) . Plays both structural and catalytic roles in numerous cytokines and interferons signaling (PubMed:10542297) . Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186) . The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:7526154, PubMed:25762719) . In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862) .

Summary: Tissue Location: Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IHC-P

Dilution: IHC-P--1:100~500 WB--1:1000

Synonyms: Non-receptor tyrosine-protein kinase TYK2, TYK2