UBAP1 Antibody (N-term) [APR06125G]

UBAP1 Antibody (N-term) [APR06125G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This UBAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-33 amino acids from the N-terminal region of human UBAP1.

Cellular Localisation: Cytoplasm, cytosol. Endosome. Note=Predominantly cytosolic (PubMed:21757351) . Recruited to endosomes as part of the ESCRT-I complex (PubMed:21757351) .

Molecular Weight: 55084

Clone: Polyclonal

Gene Name: UBAP1 {ECO:0000303|PubMed:11599797, ECO:0000312|HGNC:HGNC:12461}

Gene ID: 51271

Function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process (PubMed:21757351, PubMed:22405001, PubMed:31203368) . Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (PubMed:21757351, PubMed:22405001) . Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (PubMed:24284069, PubMed:22405001, PubMed:31203368) .

Summary: Tissue Location: Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Ubiquitin-associated protein 1, UBAP-1, Nasopharyngeal carcinoma-associated gene 20 protein, UBAP1