UBC9 Antibody (UBE2I)| F40817-0.08ML

UBC9 Antibody (UBE2I)| F40817-0.08ML | Gentaur UK, US & Europe Distribution

Background: UBE2I (Ubc9) is a member of the E2 family and is specific for the conjugation of SUMO to a variety of target proteins. SUMO conjugation to target proteins is mediated by a different, but analogous, pathway to ubiquitinylation. This E2 is unusual in that it interacts directly with protein substrates that are modified by sumoylation, and may play a role in substrate recognition. UBE2I can mediate the conjugation of SUMO-1 to a variety of proteins including RanGAP1, I?B?, and PML without the requirement of an E3 ligase. UBE2I is essential for nuclear architecture and chromosome segregation.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat, Chicken, Zebrafish, Xenopus

Application: WB, IHC, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100

Application Note: Titration of the UBC9 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This UBC9 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for this UBC9 antibody.

Storage: Aliquot the UBC9 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A