UBE2D1 Antibody (C-term) [APR04786G]

UBE2D1 Antibody (C-term) [APR04786G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This UBE2D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-140 amino acids from the C-terminal region of human UBE2D1.

Cellular Localisation: Cytoplasm.

Molecular Weight: 16602

Clone: Polyclonal

Gene Name: UBE2D1

Gene ID: 7321

Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338) . In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386) . Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941) . Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044) . Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044) . Essential for viral activation of IRF3 (PubMed:19854139) . Mediates polyubiquitination of CYP3A4 (PubMed:19103148) .

Summary: Tissue Location: Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: IHC-P--1:100 WB--1:1000 IHC-P--1:100~500

Synonyms: Ubiquitin-conjugating enzyme E2 D1, Stimulator of Fe transport, SFT, UBC4/5 homolog, UbcH5, Ubiquitin carrier protein D1, Ubiquitin-conjugating enzyme E2 (17) KB 1, Ubiquitin-conjugating enzyme E2-17 kDa 1, Ubiquitin-protein ligase D1, UBE2D1, SFT, UBC5A, UBCH5, UBCH5A