UBE3C polyclonal Antibody | BS8220

UBE3C polyclonal Antibody | BS8220 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC IF

Application Range: WB: 1:500~1:2000 IHC/IF: 1:50~1:200

Background: E3 ubiquitin ligases are a large family of proteins that are engaged in the regulation of the turnover and activity of many target proteins and are classified into three major structurally distinct types: N-end rule E3s, E3s containing the HECT (homology to E6AP C-Terminus) domain and E3s with the RING finger. UBE3C (ubiquitin protein ligase E3C), is a 1083 amino acid nuclear protein that contains one HECT domain and one IQ domain. Existing as three isoforms due to alternative splicing events, UBE3C is highly expressed in skeletal muscle and expressed at much lower levels in kidney and pancreas. UBE3C is a E3 ubiquitin-protein ligase that accepts ubiquitin from UBE2D1 (ubiquitin-conjugating enzyme E2 D1) in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. UBE3C can target itself for ubiquitination in vitro and may promote its own degradation in vivo.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: UBE3C polyclonal Antibody detects endogenous levels of UBE3C protein.

Molecular Weight: ~ 124 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Ubiquitin-protein ligase E3C; HectH2; UBE3C; KIAA0010; KIAA10

Immunogen: Recombinant full length Human UBE3C.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: